Aptamer Details

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TEPP (ID# 7201)

Aptamer Chemistry: DNA Target: bEnd.3 and MDA-MB-231 Antigen/Target Category: Cells Affinity (Kd): 110-85.6 nM (reported value) Binding Conditions/Buffer: PBS with 1mM MgCl2, 0.1 mg/mL tRNA, 1mg/mL bovine serum albumin, and 10% FCS Binding Temp: 37°C Refolding Protocol: Mfold Comments: BIFUNCTIONAL aptamer. Affinity value is not a range. First value is affinity with bEnd.3, second value is affinity with MDA

Sequence (): 5'dGpdCpdGpdCpdGpdGpdTpdApdCpdCpdGpdCpdGpdCpdTpdApdApdCpdGpdGpdApdGpdGpdTpdTpdGpdCpdGpdTpdCpdCpdGpdTp3' Length: 33 Molecular Weight: 10266.58 g/mole Extinction Coefficient: 304900 L/(mole·cm) GC Content: 69.70% nmoles/OD₂₆₀: 3.28 μg/OD₂₆₀: 33.67

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Macdonald, J., Denoyer, D., Henri, J., Jamieson, A., Burvenich, I. J., Pouliot, N., & Shigdar, S. (2020). Bifunctional aptamer–doxorubicin conjugate crosses the blood–brain barrier and selectively delivers its payload to EpCAM-positive tumor cells. Nucleic acid therapeutics, 30(2), 117-128.

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Aptamer Details

TEPP (ID# 7201)

Macdonald, J., Denoyer, D., Henri, J., Jamieson, A., Burvenich, I. J., Pouliot, N., & Shigdar, S. (2020). Bifunctional aptamer–doxorubicin conjugate crosses the blood–brain barrier and selectively delivers its payload to EpCAM-positive tumor cells. Nucleic acid therapeutics, 30(2), 117-128.

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