Aptagen, LLC
FLT3 (FMS-like Tyrosine Kinase-1) targeting aptamers (ID# 9945)
DNA
FLT3 (fms-like tyrosine kinase-1 )
Protein
0.423 ± 0.205 (For humans, reduced affinity observed for pigs and dogs) nM (reported value)
The selection was conducted in 1X D-PBS-T buffer (1X D-PBS + 0.05% Tween 20).
25°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Specificity tested against human VEGFR-2, VEGFR-3, Neuropilin-1, and Neuropilin-2 or 1000 nM (1 µM) VEGF165, PlGF, native human fibrinogen, and soluble Endoglin
A partially randomized single-stranded DNA library containing two defined artificial hydrophobic bases (Ds: 7-(2-thienyl)imidazo[4,5-b]pyridine) was synthesized. There are two positions in the random region (position 8 and 22) are replaced by T
5'-dCpdTpdGpdApdCpdCpdCpdTpdGpdCpdGpdCpdCpdGpdCpdCpdGpdApdApdGpdGpdTpdTpdGpdApdGpdGpdGpdGpdApdCpdGpdGpdGpdTpdCpdApdGpdCpdGpdCpdGpdTpdApdGpdCpdGp-3'
79
24288.6 g/mole
714200 L/(mole·cm)
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Owari, K., Piao, H., Hori, M. et al. Selective removal of soluble FLT-1 using a high-affinity DNA aptamer for potential apheresis treatment of preeclampsia. Sci Rep (2026). https://doi.org/10.1038/s41598-026-50826-2
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