Aptamer Details

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NC3S (ID# 8079)

Aptamer Chemistry: DNA

Target: N‑Cadherin

Antigen/Target Category: Protein

Affinity (Kd): 20.08 ± 0.72 nM (reported value)

Binding Conditions/Buffer: 4.5 g L−1 glucose and 5 mM MgCl2 in Dulbecco’s PBS without calcium and magnesium, yeast tRNA and BSA

Binding Temp: 4, 25, 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 47

Molecular Weight: 14499.4

Extinction Coefficient: 454400

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Gao T , Ding P , Li W , Wang Z , Lin Q , Pei R . Isolation of DNA aptamers targeting N-cadherin and high-efficiency capture of circulating tumor cells by using dual aptamers. Nanoscale. 2020 Nov 19;12(44):22574-22585. doi: 10.1039/d0nr06180h. PMID: 33174555.

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