Aptamer Details

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OS-7.9 Aptamer (ID# 8190)

Human Osteosarcoma MG-63
12.8 nM (reported value)
Phosphate-Buffered Saline (PBS) 1X with 4.5 mg/mL glucose [Acros], 5 mM MgCl2 [VWR]. 1 mg/mL bovine serum albumin (BSA). The buffers were filtered through a 0.22 um syringe filter.
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
The OS-7.9 aptamer displayed significant binding towards human colon colorectal adenocarcinoma (Widr) and human lung carcinoma (A549), implying the presence of at least one common marker.
The aptamer shows high binding affinity at 4C and 37C.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Tsogtbaatar, K., Sousa, D. A., Ferreira, D., Tevlek, A., Aydın, H. M., Çelik, E., & Rodrigues, L. (2021). In vitro selection of DNA aptamers against human osteosarcoma. Investigational New Drugs. doi:10.1007/s10637-021-01161-y

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