Aptamer Details

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VEGF receptor KDR/Flk-1 (K237) (ID# 7629)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
VEGF receptor KDR/Flk-1
N/A nM (reported value)
Washing Buffer: 0.9% NaCl, 0.01 M phosphate buffer, pH 6.2, blocked with 0.3% BSA, 25 mM HEPES (pH 7.6) for 3 h.
Disrupts the interaction between VEGF and and the KDR receptor and causes inhibition of angiogenesis and tumor growth.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Hetian et al. "A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor." J Biol Chem., 277(2002): 43137-42.

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