Aptamer Details

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S14 (SARS-CoV-2 Trimeric S Protein) (ID# 9673)

Aptamer Chemistry: DNA

Target: SARS-CoV-2 Trimeric S Protein

Antigen/Target Category: Protein

Affinity (Kd): 21.8 nM (reported value)

Binding Conditions/Buffer: 1 PBS pH 7.4, 10 mM MgCl2,50 mM KCl, 25 mM NaCl

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: G-Quadruplex

Sequence ():

Length: 44

Molecular Weight: 13912 g/mole

Extinction Coefficient: 450500 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Ankit Gupta, Anjali Anand, Neha Jain, Sandeep Goswami, Anbalagan Anantharaj, Sharanabasava Patil, Rahul Singh, Amit Kumar, Tripti Shrivastava, Shinjini Bhatnagar, Guruprasad R. Medigeshi, Tarun Kumar Sharma, A novel G-quadruplex aptamer-based spike trimeric antigen test for the detection of SARS-CoV-2, Molecular Therapy - Nucleic Acids, Volume 26, 2021, Pages 321-332, ISSN 2162-2531, https://doi.org/10.1016/j.omtn.2021.06.014.

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