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SARS-CoV-2 Variants’ Spike Protein DNA Aptamer M40 (ID# 8476)

Spike Protein of Wild Type SARS-CoV-2 Virus
155 pM (reported value)
Binding Buffer containing 20 mM Hepes, 150 mM NaCl, 5 mM KCl, 2 mM MgCl2, 0.5 mM CaCl2, pH 7.4.
94 °C for 5 minutes and let to cool at room temperature for 20 minutes
M40 showed strong binding affinity to various SARS-CoV-2 Virus including Wild-type, Alpha, Beta, Delta and Omicron with the Kd of 155pM, 280pM, 276pM, 187pM, and 165pM respectively. To be noted there is no specificity related tests in the article.
16.83 kDa

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Le TT, Benton DJ, Wrobel AG, Gamblin SJ. Development of high affinity broadly reactive aptamers for spike protein of multiple SARS-CoV-2 variants. RSC Adv. 2023 May 19;13(22):15322-15326. doi: 10.1039/d3ra01382k. PMID: 37213341; PMCID: PMC10197177.

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