Aptamer Details

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Vascular Permeability Factor/Vascular Endothelial Growth Factor (NX-213) (ID# 7547)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Vascular Permeability Factor/Vascular Endothelial Growth Factor (VPF/VEGF)
140 pM (reported value)
Selection Buffer (PBS: 10.1 mM Na2HPO4, 1.8 mM KH2PO4, 137 mM NaCl and 2.7 mM KCl (pH 7.4)) with 0.01 % human serum albumin
Heated at 90°C for 2 min and then cooled on ice.
Binding with Reduced VPF/VEGF, platelet-derived growth factor AB, basic fibroblast growth factor, antithrombin III, and thrombin was measured. Aptamer bound with >650- fold preference to target.
The sequence is denoted with d=deoxy, r=ribo, n=2'-NH2, m=2'-O-Me, s=phosphorothioate, and p=phosphate
Structure shown omits 5'- and 3'-terminal phosphorothioate thymine linkers.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Green L, Jellinek D, Janjic N, et al. (1995) "Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor." Chem Biol. 2:683-695.

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