Aptamer Details

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ErbB2 Tyrosine Kinase Receptor (Ph-12-1) (ID# 7780)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
ErbB2 Tyrosine Kinase Receptor
N/A nM (reported value)
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Binds strongly to breast cancer cell lines SKBR3, T47D, MCF-7, amd PM-1, prostate Du-145, Glioma U87MG, colon HT-2933, and lung DMS-273. Exhibits some binding to human lymphoblast lymphoma cell line K562.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Shadidi and Sioud. "Identification of Novel Peptides for the Specific Delivery of Therapeutics into Cancer Cells." The FASEB Journal, 2, (2003): 256-8.

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