Prostate-specific membrane antigen (xPSM-A9) Aptamer Details

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Prostate-specific membrane antigen (xPSM-A9) (ID# 10128)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: 2'-F-RNA

Target: Prostate-specific membrane antigen (PSMA)

Antigen/Target Category: Protein

Ki: 2.1 nM (reported value)

Binding Conditions/Buffer: 40mM Tris-HCL, pH = 7.4

Binding Temp: 37 °C °C

Refolding Protocol: Not Reported

Comments: Secondary structures may not be fully accurate due to mFold limitations in representing modified RNA chemistries. Forward and reverse primers are included.

Sequence ():

Length: 70

Molecular Weight: 21393.7 g/mole

Extinction Coefficient: 665700 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Shawn E. Lupold, Brian J. Hicke, Yun Lin, Donald S. Coffey; Identification and Characterization of Nuclease-stabilized RNA Molecules That Bind Human Prostate Cancer Cells via the Prostate-specific Membrane Antigen1. Cancer Res 15 July 2002; 62 (14): 4029–4033. http://www.ncbi.nlm.nih.gov/pubmed/12124337

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