Ofloxacin (Q2) Aptamer Details

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Ofloxacin (Q2) (ID# 10048)

Aptamer Chemistry: DNA

Target: Ofloxacin

Antigen/Target Category: Small Organic

Affinity (Kd): 0.11± 0.06 nM (reported value)

Binding Conditions/Buffer: 100 mM NaCl, 20 mM Tris–HCl pH 7.6, 2 mM MgCl2, 1 mM CaCl2

Binding Temp: Room temperature°C

Refolding Protocol: 90 °C for 8 min, 4 °C for 10 min and briefly incubation at room temperature

Specificity: Binds to quinolones with high specificity and does not bind to other tested drugs, such as antibiotics of other classes, beta blocker, and biocide

Sequence ():

Length: 98

Molecular Weight: 30319.7 g/mole

Extinction Coefficient: 954300 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

C. Reinemann, U. Freiin von Fritsch, S. Rudolph, B. Strehlitz, Generation and characterization of quinolone-specific DNA aptamers suitable for water monitoring, Biosensors and Bioelectronics, Volume 77, 2016, Pages 1039-1047, ISSN 0956-5663, https://doi.org/10.1016/j.bios.2015.10.069.

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