hCD40L-human CD40 ligand Aptamer Details

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hCD40L-human CD40 ligand (ID# 9938)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: L-DNA

Target: human CD40 ligand

Antigen/Target Category: Small Organic

Affinity (Kd): 2.55 nM (reported value)

Binding Temp: 74.7°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Not provided

Comments: Secondary structure was predicted using DNA algorithm, which may not be accurate because the aptamer is comprised of LNA bases.

Sequence ():

Length: 40

Molecular Weight: 12438.2 g/mole

Extinction Coefficient: 417500 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Lock, Protect, and Bind: In Vitro Selection of LNA-modified Aptamers Using a Mutant T7 RNA Polymerase Kevin Neis, Laia Civit, Kathrine Pedersen, Michael Schachtner, Jesper Wengel, Ralf Wagner, Steffen Thiel, Jørgen Kjems, Julián Valero bioRxiv 2025.04.09.647959; doi: https://doi.org/10.1101/2025.04.09.647959

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