Aptamer Details

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DB99 (Clone A) (ID# 8196)

21.21 nM (reported value)
1X PBS (pH 7.4) Selections carried out in vivo in six- to eight-week-old female immunodeficient BALB/c mice (CAnN. Cg-Foxn1nu/Crl).
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
No binding to A431, A172, or Molm-13 cells - GD2-deficient cell lines.
The sequence for Clone B was identified, but that construct was not studied.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Zhang, L., Wang, M., Zhu, Z., Chen, S., Wu, H., Yang, Y., Che, F., Li, Q., & Li, H. (2021). A GD2-aptamer-mediated, self-assembling nanomedicine for targeted multiple treatments in neuroblastoma theranostics. Molecular therapy. Nucleic acids, 26, 732–748. https://doi.org/10.1016/j.omtn.2021.08.021

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