1R6 (αSyn1-95) Aptamer Details

1R6 (αSyn1-95) (ID# 10145)

Aptamer Chemistry: RNA

Target: αSyn1-95 (N-terminal 95-residue fragment of αSyn)

Antigen/Target Category: Protein

Affinity (Kd): 11 nM (reported value)

Binding Conditions/Buffer: BLI assay with PBS incubation (8.1 mM Na2HPO4, 1.5 mM KH2PO4, 2.7 mM KCl, 14 mM NaCl, pH 7.4)

Binding Temp: 30°C

Refolding Protocol: RNA pool denatured at 90 °C for 10 minutes, then quickly set to ice for 30 minutes

Specificity: BLI assays show 1R6 has no affinity to C-terminal αSyn regions. In Vivo assays demonstrated therapeutic benefits of aptamer only to αSyn pathology, not to AB or tau phenotypes

Sequence ():

Length: 29

Molecular Weight: 8803.6 g/mole

Extinction Coefficient: 253100 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Murakami, K., Van Nguyen, T.H., Tsuda, L. et al. Development of an RNA aptamer as a therapeutic agent for synucleinopathies. Nat Commun 17, 7118 (2026). https://doi.org/10.1038/s41467-026-75209-z

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