Aptamer Details

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Seq-2 (ID# 8189)

Aptamer Chemistry: DNA

Target: Unknown tumor marker - colorectal cancer

Antigen/Target Category: Protein

Affinity (Kd): 11.31 nM (reported value)

Binding Conditions/Buffer: 1X PBS solution at a pH of 7.4 incubated at 37°C for 1 hour.

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Specific to colorectal cancer patient serum samples over multifarious serum proteins found in gastric, cervical, and lung cancer patient samples.

Sequence ():

Length: 88

Molecular Weight: 26842.4

Extinction Coefficient: 810200

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Li, K., Qi, L., Gao, L. M., Shi, M., Li, J., Liu, Z. W., & Zhao, L. (2019). Selection and preliminary application of a single stranded DNA aptamer targeting colorectal cancer serum. RSC Advances, 9(66), 38867–38876. https://doi.org/10.1039/c9ra04777h

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