Aptamer Details

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5TRG2 (ID# 7987)

Aptamer Chemistry: RNA

Target: MUC1-5TR-GalNAc; Tn antigen

Antigen/Target Category: Protein

Affinity (Kd): 18.6 nM (reported value)

Binding Conditions/Buffer: 150 nM NaCl, 5nM MgCl2, pH 7.4

Binding Temp: 37°C

Refolding Protocol: Refolded in binding conditions

Specificity: See figure 3 in article reference

Comments: Target is O-linked glycan-peptide specific to epithelial cancer cells. Sequence is 5'-dGpdApdGpdApdCpdApdApdGpdApdApdTpdApdApdApdCpdGpdCpdTpdCpdApdApdGpdGpdCpdTpdApdTpdApdGpdCpdApdCpdApdTpdGpdGpdGpdTpdApdApdApdApdCpdGpdApdCpdTpdTpdCpdGpdApdCpdApdGpdGpdApdGpdGpdCpdTpdCpdApdCpdApdApdCpdApdGpdGpdCp-3'

Sequence ():

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Ferreira, C.S.; Cheung, M.C.; Missailidis, S.; Bisland, S.; Gariepy, J. Phototoxic aptamers selectively enter and kill epithelial cancer cells. Nucleic acids research 2009, 37, 866-876.

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