Aptamer Details

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Gonadotropin-releasing hormone 1 (A10) (ID# 7492)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Gonadoliberin/Gonadotropin-releasing hormone 1 (GnRH)
190 nM (reported value)
Selection Buffer: 10 mM HEPES (pH 7.5), 137 mM NaCl, 2.7 mM KCl, 2 mM CaCl22, 1 mM MgCl2, 0.005% Triton X-100
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Fifty-fold difference in affinity between GnRH and chicken LHRH.
Five-fold difference in affinity between GnRH and Buserelin.
Reduced Ca2+ release in Chinese hamster ovary cells transfected with human GnRH receptor with an IC50 value of 200 nM.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Leva, S., et al. "GnRH Binding RNA and DNA Spiegelmers: A Novel Approach toward GnRH Antagonism." Chemistry and Biology, 9 (2002): 351-359.

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