Aptamer Details

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SE43 (ID# 8191)

Aptamer Chemistry: DNA

Target: Staphylococcus epidermidis

Antigen/Target Category: Cells

Binding Conditions/Buffer: PBS for selection; PBS containing 1% BSA and 0.05% Tween20 for binding assay

Binding Temp: 23°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Highly specific to Staphylococcus epidermidis and not specific towards human platelets and plasma

Comments: Designed to eliminate bacteria from platelet units to improve the safety of blood transfusions. Aptamer is not DNA, but FNA chemistry.

Sequence ():

Length: 76

Molecular Weight: 23501.2

Extinction Coefficient: 729700

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Kaur SJ, Gilman V, Duong M, Asher DM, Gregori L. Rapid selection of single-stranded DNA aptamers binding Staphylococcus epidermidis in platelet concentrates. Biotechniques. 2018 Dec;65(6):331-338. doi: 10.2144/btn-2018-0081. PMID: 30477331.

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