Aptamer Details

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SL1111_20 (ID# 8240)

RBD of SARS-COV-2 Spike protein (monomer or trimer)
0.4-0.5 nM (reported value)
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
This is a truncated sequence cut from 5'-CCTTGGGAYAPYAYGPGYPPGAPPGPYPGGAPGGAGAAGG-3', a SOMAmer. P= NapdU.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Gelinas, A. D., Tan, T. K., Liu, S., Jaramillo, J. G., Chadwick, J., Harding, A. C., Zhang, C., Ream, B. E., Chase, C. N., Otis, M. R., Lee, T., Schneider, D. J., James, W. S., & Janjic, N. (2023). Broadly neutralizing aptamers to SARS-COV-2: A diverse panel of modified DNA antiviral agents. Molecular Therapy - Nucleic Acids, 31, 370–382. https://doi.org/10.1016/j.omtn.2023.01.008

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