Aptamer Details

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SL1111_20 (ID# 8240)

Aptamer Chemistry: DNA

Target: RBD of SARS-COV-2 Spike protein (monomer or trimer)

Antigen/Target Category: Protein

Affinity (Kd): 0.4-0.5 nM (reported value)

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: This is a truncated sequence cut from 5'-CCTTGGGAYAPYAYGPGYPPGAPPGPYPGGAPGGAGAAGG-3', a SOMAmer. P= NapdU.

Sequence ():

Length: 29

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Gelinas, A. D., Tan, T. K., Liu, S., Jaramillo, J. G., Chadwick, J., Harding, A. C., Zhang, C., Ream, B. E., Chase, C. N., Otis, M. R., Lee, T., Schneider, D. J., James, W. S., & Janjic, N. (2023). Broadly neutralizing aptamers to SARS-COV-2: A diverse panel of modified DNA antiviral agents. Molecular Therapy - Nucleic Acids, 31, 370–382. https://doi.org/10.1016/j.omtn.2023.01.008

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