Aptamer Details

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OSM (ADR58) (ID# 7499)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Human Oncostatin M (OSM)
7 nM (reported value)
Wash Buffer: 0.1% I-block, 0.05% Tween 20 in SCHMK buffer (110 mM NaCl, 1 mM MgCl2, 20 mM HEPES (pH 7.0), 1 mM CaCl2, 5 mM KCl)
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Can specifically antagonize OSM by binding to the gp130 receptor.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Rhodes, Andrew, et al. "The generation and characterization of antagonist RNA aptamers to human oncostatin M." Journal of Biological Chemistry, 275 (2000): 28555-28561.

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