Aptamer Details

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LZH5B (ID# 8024)

Aptamer Chemistry: DNA

Target: HepG2 Liver Cancer Cells

Antigen/Target Category: Cells

Affinity (Kd): 12 nM (reported value)

Binding Conditions/Buffer: 1x PBS with 5mM MgCl2

Binding Temp: 37°C

Refolding Protocol: Heated to 95C for 5 minutes and snap cooled to 4C.

Comments: Hachimoji DNA. Currently using PNA "pTn" as placeholders for 2-amino-8-(1′-b-D-2′-deoxyribofuranosyl)-imidazo-[1,2a]-1,3,5-triazin-[8H]-4-one bases (Hachimoji base P)

Sequence ():

Length: 43

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Zhang, L., Wang, S., Yang, Z., Hoshika, S., Xie, S., Li, J., …Tan, W. (2019). An Aptamer‐Nanotrain Assembled from 6‐Letter DNA Delivers Doxorubicin Selectively to Liver Cancer Cells. Angewandte Chemie. doi:10.1002/ange.201909691

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