Aptamer Details

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HIV-Reverse Transcriptase Aptamer 2.7-1008 (ID# 8470)

HIV Reverse Transcriptase
Small Organic
1.10 nM (reported value)
BLI Binding Buffer - 10 mM N-(2-hydroxyethyl)piperazine-N′-ethanesul fonicacid (HEPES), pH=7.0, 150mM NaCl, 1mM MgCl2,1 mM CaCl2, and 0.05% Tween20
95°C for 5min and cooling on ice for 20min
This Aptamer is characterized as a TNA aptamer, this means that the sugar back bone uses threose nucleic acids instead of deoxyribose nucleic acids. Instead of the normal 3' to 5' bonds there are a 3' to 2' bonds.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Parameterizing the Binding Properties of XNA Aptamers Isolated from a Low Stringency Selection Nandini Kundu, Cailen M. McCloskey, Mohammad Hajjar, and John C. Chaput Biochemistry 2023 62 (22), 3245-3254 DOI: 10.1021/acs.biochem.3c00352

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