Aptamer Details

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Hepatocyte Growth Factor Receptor (CLN0003) (ID# 7860)

Aptamer Chemistry: DNA

Target: HGF-R / c-Met

Antigen/Target Category: Protein

Affinity (Kd): 0.091 nM (reported value)

Binding Conditions/Buffer: Binding Buffer: DPBS with 0.05% BSA

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: The aptamer bound to c-Met positive cell lines GTL-16, MKN-45, and EBC-1 and not to the c-Met negative cell line Jurkat E6.1.

Sequence ():

Length: 84

Molecular Weight: 26296.09

Extinction Coefficient: 815800

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Boltz A, Plater B, Hock B, et al. (2011) Bi-specific Aptamers Mediating Tumour Cell Lysis. J Biol Chem. 286: 21896-21905

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