Aptamer Details

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Diversely Functionalized Human alpha-Thrombin Aptamer (ID# 8028)

Aptamer Chemistry: DNA

Target: Human alpha-Thrombin

Antigen/Target Category: Protein

Affinity (Kd): 1.6 nM (reported value)

Binding Conditions/Buffer: 20 mM Tris-HCl pH 7, 140 mM NaCl, 5mM KCl, 1 mM MgCl2, 1 mM CaCl2

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: This aptamer is highly functionalized. See paper for details.

Sequence ():

Length: 76

Molecular Weight: 23.338 kDa

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

DOI: 10.1021/jacs.7b07241 J. Am. Chem. Soc. 2017, 139, 13977−13980

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