Aptamer Details

Back to Search Results

Aptamer MA (ID# 8176)

methylenedioxypyrovalerone (MDPV)
Small Organic
7 nM (reported value)
10 mM Tris–HCl, 0.5 mM MgCl2, 20 mM NaCl, pH 7.4
heated at 95◦C for 5min, slowly cooled to room temperature over 30 min
Highly Specific
This aptamer intrinsically binds Cy7 within its TWJ domain, but MDPV efficiently displaces the dye, resulting in a change in absorbance within seconds. This allows this aptamer to act as a label free assay.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Haixiang Yu, Weijuan Yang, Obtin Alkhamis, Juan Canoura, Kyung-Ae Yang, Yi Xiao, In vitro isolation of small-molecule-binding aptamers with intrinsic dye-displacement functionality, Nucleic Acids Research, Volume 46, Issue 8, 4 May 2018, Page e43, https://doi.org/10.1093/nar/gky026

Have your aptamer oligo synthesized ORDER