Aptamer Details

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Thrombopoietin Receptor (AF12505) (ID# 7661)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Thrombopoietin Receptor
2 nM (reported value)
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
The authors also created a dimerized version of AF12505 (AF13948). This peptide aptamer possessed an IC50 of 0.5 nM and EC50 4000 times that of the monomer.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Cwirla et al. "Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine." Science, 276(1997): 1696-1699.

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