Aptamer Details

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AP-1 (ID# 8111)

Aptamer Chemistry: DNA

Target: Proprotein Convertase Subtilisin/Kexin 9

Antigen/Target Category: Protein

Affinity (Kd): 294 nM (reported value)

Binding Conditions/Buffer: 25 mM Tris-HCl, 192 mM glycine, 5 mM KH2PO4, and pH 8.3

Binding Temp: 37°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 88

Molecular Weight: 27041.5

Extinction Coefficient: 835800

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Sattari R, Palizban A, Khanahmad H. Single-Strand DNA-Like Oligonucleotide Aptamer Against Proprotein Convertase Subtilisin/Kexin 9 Using CE-SELEX: PCSK9 Targeting Selection. Cardiovasc Drugs Ther. 2020 Aug;34(4):475-485. doi: 10.1007/s10557-020-06986-y. PMID: 32415571.

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