Aptamer Details

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BI1 (ID# 8220)

N/A nM (reported value)
4.5 g glucose, 100 mg tRNA, 50 mg of salmon sperm DNA, 1 g BSA, and 5 mL of 1 M MgCl21 in 1 L of DPBS
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Researchers mention that BI1 is specific to beta-secretase and not alpha- or gamma-secretase.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Jun Xiang, Wen Zhang, Xiao-Fang Cai, Min Cai, Zhong-Hai Yu, Feng Yang, Wen Zhu, Xiang-Ting Li, Ting Wu, Jing-Si Zhang, Ding-Fang Cai, DNA Aptamers Targeting BACE1 Reduce Amyloid Levels and Rescue Neuronal Deficiency in Cultured Cells, Molecular Therapy - Nucleic Acids, Volume 16, 2019, Pages 302-312, ISSN 2162-2531.

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