• We Guarantee Our Services.
  • Customer Owns 100% of the IP.
  • "…taking on Challenging Projects and Delivering Positive Results."

Company Profile

Aptagen, LLC is a global leader in aptamer development with over 25 years of experience generating high affinity and specifically-binding aptamers for small molecules, proteins, cells, and tissues. We produce state-of-the-art target-recognition elements for diagnostics, therapeutics, and bio-industrial applications. 

Aptagen has grown from a one-man operation with the ingenuity and support of interns, graduate students, and post-docs to a tight-knit developing business with a world-class team of scientists, servicing clients ranging globally from research academics at top-tier institutions to BigPharma companies. Aptagen was named as a finalist for the “Top Emerging Business of the Year” of 2011 by Central Penn Business Journal. Aptamers are an emerging technology that is poised to become the next evolution in diagnostics and drug discovery. Aptagen continues to play a leading role in developing aptamer technology that will assist in the treatment and diagnosis of various diseases.  Today, Aptagen is a leader in the field of aptamers and has a strong reputation for “Taking on Challenging Projects, and Delivering Positive Results.”

Aptagen was formed in 2004, and operations began two years later  in 2006.  Aptagen is located in Jacobus, PA, a suburb of York, beautifully surrounded by hiking and horseback riding trails near Lake Williams and Lake Redman. We are conveniently situated off of Interstate 83.  The facility is a forty-minute drive from Johns Hopkins University and Hershey Medical Center.

G. Thomas Caltagirone,
President & CEO
ext. 500

Dr. Caltagirone, who has over 25 years of research and business experience in start-ups, is the President & CEO of Aptagen, LLC.  A native of York, PA, he began his studies at the University of the Sciences in Philadelphia with a bachelor’s degree in Biochemistry followed by a Ph.D. in Neuroscience from Drexel University. He completed his thesis on “Proton-Sensitive Ribozyme Switches with Molecular Memory” at Yale University. His training and technical skills are primarily in the area of Molecular Biology with several patents and publications under his name.

Michelle L. Young
Administrative Assistant
ext. 301

Michelle is originally from Lancaster, Pennsylvania. She earned her Associates Degree from Consolidated School of Business. Before coming to Aptagen, she was a judicial secretary. She has over 10 years’ experience in an office setting.

Albert M. Liao, BS
Lab Director / ext. 508

Albert Liao earned his bachelor’s degree from Johns Hopkins University in the field of Biomedical Engineering. He then participated in the internship program and graduated to assume the Lab Director position. In his time at Aptagen, Albert contributed to many aspects of the lab, including Aptamer R&D and Oligonucleotide Synthesis.

Tran Thanh Thoa, Ph.D.
Research Scientist

Tran Thanh Thoa earned her Ph.D. from Tokyo Metropolitan University, Japan in 2017. Since 2017, she had worked as a Research Professor at Korea University, and subsequently, she has served as a research scientist at the Institute of Fluid Mechanics (LSTME) Busan.

Shailaja Agrawal, Ph.D.
Research Scientist

Shailaja Agrawal is an experienced Research Director with a history of working in the higher education industry. She is skilled in Good Laboratory Practice (GLP), SDS-PAGE, Molecular Biology, Biotechnology, and Cell Culture. Her doctorate degree in Biotechnology is from Savitribai Phule Pune University.

How to Apply
Graduated (DNA Helix Trophy) (DNA Helix Trophy) = Graduated & fulfilled all requirements of the Aptagen Internship Program.

Aptagen Interns

Jeffrey Bardwell
Jeffrey Bardwell Baylor University Ph. D. Biology 09/21 - Present
Lan Le
Lan Le University of Washington, Seattle Chemistry 09/21 - Current
Faisal Muharraq
Faisal Muharraq Drexel University M.S. Biomed Engineering 09/21 - Present
Eveline M. Tardes
Eveline M. Tardes Penn State University B.S., Biology 09/21 - Present
David E. Wiggins
Graduated (DNA Helix Trophy) David E. Wiggins Rensselaer Polytech Inst B.S. Biochem./Biophysics 06/21- 11/21
Hannah E. Reed
Hannah E. Reed York College of PA B. S. Biology 06/21 - Present
Timothy K. Freda
Graduated (DNA Helix Trophy) Timothy K. Freda University of the Sciences M.S. Genomics 06/21 - 11/21
Tim Shokri
Tim Shokri Penn State University M.S. Chemical 06/21 - 07/21
Veera V. Basamshetty
Veera V. Basamshetty Nat'l Inst. of Pharm Guwahati Ph.D. Biotechnology 03/21 - Present
Fatima Kazmi
Fatima Kazmi Stevens Inst. of Tech. M.S. Biomedical Eng. 03/21 - 07/21
Leah E. Knepper
Leah E. Knepper Geneva College B.S. Chemistry 01/21 - 06/21
Lina K. Betu
Lina K. Betu Univ of MD College Park B.S. Bioengineering 01/21 - 05/21
Kaili Ji
Kaili Ji Nat'l Univ of Singapore Ph.D. Analytical Biochemistry 07/20 - 03/21
Wesley C. Reindel
Graduated (DNA Helix Trophy) Wesley C. Reindel Univ of South Carolina B.S. Biomedical Engineer 09/20 - 03/21
Thu Thuy Ha
Graduated (DNA Helix Trophy) Thu Thuy Ha Univ of South Carolina B.S. Biology 09/20 - 03/21
Maranda S. Gibb
Graduated (DNA Helix Trophy) Maranda S. Gibb York College of PA B.S. Biology 09/20 - 03/21
Katherine L. Brooks
Katherine L. Brooks Univ of Delaware B.S. Biotech & Applied Biology 09/20- 01/21
Jessica Rodriguez
Graduated (DNA Helix Trophy) Jessica Rodriguez Penn State Univ B.S. Pharmacology & Toxicology 09/20- 03/21
Trung 'Jay' Le
Graduated (DNA Helix Trophy) Trung 'Jay' Le Univ of Virginia M.E. Chemical Engineering 06/20 - 12/20
Rebecca L. Rose
Graduated (DNA Helix Trophy) Rebecca L. Rose York College of PA Chemistry 06/20 - 12/20
James S. Vandegrift
Graduated (DNA Helix Trophy) James S. Vandegrift Ursinus College B.S. Chemistry 06/20 - 12/20
Deanna M. Dahir
Graduated (DNA Helix Trophy) Deanna M. Dahir Penn State Univ M.S. of Biotechnology 06/20 - 12/20
Daniel T. Dreyfus
Daniel T. Dreyfus Univ of Delaware B.A. Biological Sciences 06/20 - 10/20
Jorge L. Garcia
Jorge L. Garcia Univ of Pittsburgh Neuroscience 01/20 - 05/20
Meredith D. Davis
Graduated (DNA Helix Trophy) Meredith D. Davis Dickinson College Biochem & Molecular Bio 09/19 - 03/20
Brianna L. Ankney
Graduated (DNA Helix Trophy) Brianna L. Ankney Univ of Pittsburgh Biology & Chemistry 09/19 - 03/20
W. Nate Hoxie
Graduated (DNA Helix Trophy) W. Nate Hoxie UMBC Chemistry 06/19 - 12/19
Jacob R. Shaw
Graduated (DNA Helix Trophy) Jacob R. Shaw Towson University Molecular Biology 09/18 - 5/19
Andrew Yuhas
Andrew Yuhas University of the Sciences Biology 09/18 - 12/18
Lauren A. Smith
Graduated (DNA Helix Trophy) Lauren A. Smith George Mason University Bioengineering 09/18 - 2/19
Mangyin 'Matthew' Mo
Graduated (DNA Helix Trophy) Mangyin 'Matthew' Mo Penn State University Biomedical Engineering 06/18 - 12/18
Benjamin J. Rose
Benjamin J. Rose Penn State University Biochem & Molecular Bio 01/18 - 07/18
Jay Patel
Graduated (DNA Helix Trophy) Jay Patel Penn State University Chemical Engineering 01/18 - 07/18
Aaron J. Embry
Graduated (DNA Helix Trophy) Aaron J. Embry Millersville University BAS. Biology 06/17 - 02/18
Anna M. Waite
Anna M. Waite Rutgers University Masters of Science 05/17 - 12/17
James S. Lyons, Jr
Graduated (DNA Helix Trophy) James S. Lyons, Jr University of Maryland Ph.D. Candidate, Molecular Medicine 06/16 - 12/16
Adam D. Poff
Graduated (DNA Helix Trophy) Adam D. Poff Gettysburg College Biochem & Molecular Bio 05/16 - 03/17
Erika Gedvilaite
Graduated (DNA Helix Trophy) Erika Gedvilaite Penn State University MS, Biotechnology 05/16 - 12/16
Melanie Hardy
Graduated (DNA Helix Trophy) Melanie Hardy University of Maryland Biochemistry/Math 03/15 - 09/15
J. Cory Benson
Graduated (DNA Helix Trophy) J. Cory Benson Arcadia University Biology 09/14 - 05/15
Brittany Copenhaver
Graduated (DNA Helix Trophy) Brittany Copenhaver York College of PA Biology 05/14 - 01/15
Jenny Liu
Graduated (DNA Helix Trophy) Jenny Liu John Hopkins University M.S.E. in Chemical & Biomolecular Engineering 01/14 - 08/14
Robert Nwokonko
Graduated (DNA Helix Trophy) Robert Nwokonko Kutztown University Biology/Pre-medical 07/13 - 04/14
Raphael Williams, BS
Raphael Williams, BS Clarion University Molecular Biology 06/13 - 11/13
Andrew Sutton, BS
Graduated (DNA Helix Trophy) Andrew Sutton, BS York College Biology 04/13 - 11/13
Sara Wing
Sara Wing York College Biology and Chemistry 09/12 - 02/13
Tsai-Chin (Donna) Wu, Ph.D.
Tsai-Chin (Donna) Wu, Ph.D. University of Illinois Bioengineering/Nanotechnology 08/12 - 03/13
Matthew J. Murray, BS
Matthew J. Murray, BS Dickinson College Physics 07/12 - 03/13
Houng Nguyen
Houng Nguyen Penn State Biology 06/12 - 12/12
Jennifer Minteer, BS
Jennifer Minteer, BS Harrisburg University Biotechnology 06/12 - 11/12
Amiee M. Green, BS
Amiee M. Green, BS Kutztown University Biology 05/12 - 10/12
Kelsey Weren
Kelsey Weren Gettysburg College Biology 01/12 - 05/12
Matthew Gladfelter
Graduated (DNA Helix Trophy) Matthew Gladfelter York College Mechanical Engineering 01/12 - 02/13
Albert M. Liao, BS
Graduated (DNA Helix Trophy) Albert M. Liao, BS Johns Hopkins University Biomedical Engineering 01/12 - 10/12
Caitlin Nealin, M.S.
Graduated (DNA Helix Trophy) Caitlin Nealin, M.S. Georgetown University Biotechnology 10/11 - 04/12
Chelsea N. Thompson
Chelsea N. Thompson Millersville University Biology 05/11 - 12/11
Kyle Kentch, B.S.
Graduated (DNA Helix Trophy) Kyle Kentch, B.S. University of Rochester Biomedical Engineering 03/11 - 12/11
Kevin P. Jackson, BS
Graduated (DNA Helix Trophy) Kevin P. Jackson, BS Liberty University Biology with Pre-Med 11/10 - 09/11
Amy R. Smith, BS
Amy R. Smith, BS Temple University Biology/Biochemistry 11/10 - 03/11
Norman Rogers, BS
Norman Rogers, BS Salisbury University Biology 10/10 - 03/11
Christopher Dower, BS
Graduated (DNA Helix Trophy) Christopher Dower, BS Millersville University Biological Sciences 10/10 - 08/11
Dane Kikola
Graduated (DNA Helix Trophy) Dane Kikola Millersville University Biology 09/10 - 08/11
Anne Nixon, BS
Graduated (DNA Helix Trophy) Anne Nixon, BS Penn State University Biology 080/10 - 06/11
Katherine E. Eisner
Katherine E. Eisner Loyola University Biology 06/10 - 09/10
Kristen Sheaffer
Graduated (DNA Helix Trophy) Kristen Sheaffer Millersville University Biology 05/10 - 01/11
Aaron Montani
Graduated (DNA Helix Trophy) Aaron Montani Millersville University Biology 05/10 - 01/11
Dionisi Daoularis
Dionisi Daoularis Drexel University Biomedical Engineering 05/10 - 09/10
Sakkaphan Sawatphanit
Graduated (DNA Helix Trophy) Sakkaphan Sawatphanit Bucknell University Biochemistry 12/09 - 08/10
C. Nicole Groves, BS
Graduated (DNA Helix Trophy) C. Nicole Groves, BS Towson University Biology 07/09 - 06/10
Marija Debeljak
Graduated (DNA Helix Trophy) Marija Debeljak Millersville University Biology 06/09 - 04/10
Jason Huska
Graduated (DNA Helix Trophy) Jason Huska Millersville University Molecular Biology 05/09 - 20/10
Karen Kofroth
Karen Kofroth Millersville University Molecular Biology 04/09 - 08/09
Ron Ho
Ron Ho York College Biology/Pre-medical 02/09 - 06/09
Jamie S. Harper
Graduated (DNA Helix Trophy) Jamie S. Harper York College Biology 01/09 - 10/09
Nadine Chase, BS
Graduated (DNA Helix Trophy) Nadine Chase, BS Penn State York Science 12/08 - 07/10
Derek J. Jendras
Graduated (DNA Helix Trophy) Derek J. Jendras York College Biology 07/08 - 05/09
Andy L. Ngo, BS
Graduated (DNA Helix Trophy) Andy L. Ngo, BS York College Biology 07/08 - 06/09
Bethany N. nEILL
Bethany N. nEILL Franklin & Marshall College Biology 05/08 - 11/08
Mitchell B. Crawford
Graduated (DNA Helix Trophy) Mitchell B. Crawford Millersville University Molecular Biology 05/08 - 01/09
Raisa Janella N. Cheng
Raisa Janella N. Cheng York College Biology 05/08 - 11/08
Shelly L. Wesner, BS
Graduated (DNA Helix Trophy) Shelly L. Wesner, BS York College Biology 02/08 - 06/08
Jose L. Pelliccia, BS
Graduated (DNA Helix Trophy) Jose L. Pelliccia, BS Millersville University Biology, Molecular/Biotech 01/07 - 08/08
Elliot Eckard
Graduated (DNA Helix Trophy) Elliot Eckard Penn State York Science 01/07 - 07/10
Vladimir Torres
Graduated (DNA Helix Trophy) Vladimir Torres Millersville University Molecular Biology 01/07 - 01/08
Sameer Shah
Graduated (DNA Helix Trophy) Sameer Shah Millersville University Biology, Molecular/Biotech Option 01/07 - 12/07
Alexis Norris
Alexis Norris Millersville University Molecular Biology 01/06 - 01/07