Aptamer Details

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Ancrod-55 (ID# 8224)

Aptamer Chemistry: DNA

Target: ancrod

Antigen/Target Category: Protein

Affinity (Kd): 3.0 nM (reported value)

Binding Conditions/Buffer: 50 mM Tris-HCl, pH 7.5 150 mM NaCl 2 mM MgCl2

Binding Temp: 23°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: ALISA showed binding to native venom as well as venoms of some other snake species

Sequence ():

Length: 40

Molecular Weight: 12292.93

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Alomran, N, Raja, C, Alsolaiss, J, Casewell, NR, Zourob, M. (2022) Exploring the utility of ssDNA aptamers directed against snake venom toxins as new therapeutics for snakebite envenoming. Toxins, 14, 469. https://doi.org/10.3390/toxins14070469.

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