Aptamer Details

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CD59 (sp22) (ID# 7746)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
N/A nM (reported value)
Washed with cold PBS and glycine buffer added. Chilled on ice for 15 minutes.
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Inhibits CD59 expression; Concomitantly, sp22 increases complement-mediated lysis and apoptosis signals.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Li et al. "Identification of a novel short peptide seal specific to CD59 and its effect on HeLa cell growth and apoptosis." Cell Oncol. 35:355-365.

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