Aptamer Details

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4-1BB ligand (M12-23) (ID# 7724)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
4-1BB ligand on CD8+ T Cells
40 nM (reported value)
Low Salt Binding Buffer: 20 mM Hepes, pH 7.4; 50 mM NaCl; 2 mM CaCl2 ;0.01% BSA.
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
The authors constructed a bivalent version of the aptamer capable of constimulating CD8+ in vitro.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

J. O. McNamara II et al.. Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. J. Clin. Invest. 118(2008):376-386.

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