Aptamer Details

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XMU3 (ID# 8092)

Aptamer Chemistry: DNA

Target: epithelial cell adhesion molecule (EpCAM)

Antigen/Target Category: Cells

Affinity (Kd): 9.3 ± 1.3 nM (reported value)

Binding Conditions/Buffer: PBS containing 0.55 mM MgCl2 and 0.2 mg/mL yeast tRNA, pH = 7.4

Binding Temp: 25°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 92

Molecular Weight: 28366.3

Extinction Coefficient: 860500

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Huang, M., Li, T., Xu, Y., Wei, X., Song, J., Lin, B., … Yang, C. J. (2020). Activation of Aptamers with Gain‐of‐Function by Small‐Molecule‐Clipping of Intramolecular Motifs. Angewandte Chemie International Edition. doi:10.1002/anie.202013570

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