Aptamer Details

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P-Selectin (PF377) (ID# 7614)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
N/A nM (reported value)
Washed with PBS and 0.9 mM CaCl2, 0.5 mM MgCl2, 2.67 mM KCl, 1.47 mM KH2PO4, 135 mM NaCl, and 8 mM Na2.
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Also see aV??3 Clone 17.16 , which prevents the binding of sickle cell RBCs to HUVECs.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Burnette et al. "RNA Aptamer Therapy for Vaso-Occlusion in Sickle Cell Disease." Nucleic Acids Therapeutics, 21(2011): 275-283. Jenison et al. "Oligonucleotide Inhibitors of P-Selectin Dependent Neutrophil-Platelet Adhesion." Antisense & Nucleic Acid Development, 8(1998): 265-279.

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