Aptamer Details

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Paromomycin (LS11) (ID# 7802)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Paromomycin and other Aminoglycosides (AMGs)
Small Organic
19.8 nM (reported value)
Binding Buffer: PBS with 10% (v/v) methanol
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Binds to several aminoglycosides: kanamycin, paromycin streptomycin, apramycin, tobramycin, neomycin, and gentamycin.
See also aptamer LGA11 which targets the same aminoglycosides.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.

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