A23P6 Aptamer against IL-23 (P19 subunit) Aptamer Details

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A23P6 Aptamer against IL-23 (P19 subunit) (ID# 9183)

Aptamer Chemistry: DNA

Target: IL-23 (P19 subunit)

Antigen/Target Category: Protein

Affinity (Kd): 2.139 nM (reported value)

Binding Conditions/Buffer: 50 mM phosphate, 300 mM NaCl

Binding Temp: 37°C

Refolding Protocol: Heated at 95°C for 5 min, Cooled to room temperature for 30 min before binding studies

Specificity: Showed strong binding to IL-23 (P19 subunit) , no reported cross-reactivity with IL-12 or IL-27 (which share the P40 subunit)

Comments: Identified through TA cloning of SELEX-selected aptamers High affinity for IL-23, making it a candidate for biomarker detection Predicted to form stable loop structures

Sequence ():

Length: 80

Molecular Weight: 24644.9 g/mole

Extinction Coefficient: 748400 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Mohammad Ali Rezaee, Saeideh Sadat Shobeiri, Malihe Moghadam, Kazem Mashayekhi, Mojtaba Sankian, In vitro identification of single-stranded DNA aptamers targeting human IL-23 using the protein-SELEX strategy, Journal of Pharmaceutical and Biomedical Analysis, Volume 247, 2024, 116245, ISSN 0731-7085, https://doi.org/10.1016/j.jpba.2024.116245.

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