Aptamer Details

Back to Search Results

CoV2-6C3 (ID# 8195)

Aptamer Chemistry: DNA

Target: SARS-CoV-2 Spike Protein RBD

Antigen/Target Category: Protein

Affinity (Kd): 44.78 nM (reported value)

Binding Conditions/Buffer: 1X PBS, pH=7.4, including 136.8 mM NaCl, 10.1 mM Na2HPO4, 2.7 mM KCl, 1.8 mM KH2PO4, 0.55 mM MgCl2

Binding Temp: 25°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Recognizes baculovirus-insect-expressed RBD and HEK293-expressed RBD, as well as SARS-CoV-2 Spike proteinLow response to Spike protein from MERS-CoV, HCoV-HKU1, HIV-1 gp120

Sequence ():

Length: 46

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Sun, M., Liu, S., Wei, X., Wan, S., Huang, M., Song, T., Lu, Y., Weng, X., Lin, Z., Chen, H., Song, Y., & Yang, C. (2021). Aptamer Blocking Strategy Inhibits SARS-CoV-2 Virus Infection. Angewandte Chemie (International ed. in English), 60(18), 10266–10272. https://doi.org/10.1002/anie.202100225

Have your aptamer oligo synthesized ORDER