Aptamer Details

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Angiogenic endothelial cells (ID# 7632)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Aminopeptidase N
N/A nM (reported value)
Wash buffer in cellular association assays: PBS.
Peptides were also delivered in vivo to mice.
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Authors conjugated the NGR motif to liposomal doxorubicin and used the conjugate to selectively target xenograft neuroblastoma tumors in mice. See reference for details.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Pastorino et al. "Vascular Damage and Anti-angiogenic Effects of Tumor Vessel-Targeted Liposomal Chemotherapy." Cancer Research, 63(2003): 7400-7409.

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