Aptamer Details

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Human Immunoglobulin G (IgG) (Apt 8-2) (ID# 7740)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
90.9 nM (reported value)
Binding Buffer (145mM NaCl, 5.4 mM KCl, 0.8mM MgCl, 1.8 mM CaCl, and 20 mM Tris-HCl (pH 7.6))
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Specific for Human IgG, subclasses hIgG1 through hIgG4.
Does not bind to mouse, rat, rabbit, bovine, chicken, canine, feline, and guinea pig IgG.
This aptamer binds to the Fc domain of hIgG.
In picture of aptamer, lowercase letters are deoxynucleotide residues and uppercase letters are ribonucleotide or 2'-F-ribonucleotide residues.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.

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