Aptamer Details

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OX40 (Aptamer 9.8) (ID# 7726)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Murine OX40 (a tumor necrosis factor (TNF) receptor on the surface of T Cells)
8 nM (reported value)
Binding Buffer: 150 mM NaCl, 2 mM CaCl2, and 20 mM Hepes (pH 7.4)
Heated to 95°C for 5 min, then cooled slowly to room temperature.
This aptamer was dimerized using a DNA linker (5ƒ??- TCTCGGATCCTCAGCGAGT- 18 carbon spacer -TCTCGGATCCTCAGCGAGT-3ƒ??) with sequences complementary to the 3' end of the aptamer.

The dimerized version of this aptamer was capable of crosslinking and activating murine OX40 receptors, promoting cell proliferation and NF??

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

C M Dollins et al. Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer. Chem Biol. 15(2008):675-682.

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