Aptamer Details

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C-Reactive Protein (CRP1-1) (ID# 7818)

C-Reactive Protein (CRP)
2.25 nM (reported value)
Binding Buffer: 20 mM Tris-HCl (pH 7.5), 140 mM NaCl, 2 mM CaCl2 and 1 mM MgCl2.
Incubation Time: 30 min.
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Binding experiments indicate that CaCl2 is necessary for binding, suggesting that the aptamer targets the pentamer form of CRP or that the aptamer itself requires CaCl2 to bind.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

N Orito, Y Kikuchi, et al. High-affinity RNA aptamers to C-reactive protein (CRP): newly developed pre-elution methods for aptamer selection. J. Phys. Conf. Ser. 352(2012): 012042. doi:10.1088/1742-6596/352/1/012042.

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