Aptagen, LLC
Lung Cancer Serum (Apt-43) (ID# 10109)
DNA
Lung cancer serum
Other
64.0 ± 3.6 nM (reported value)
Phosphate-buffered saline (PBS) with 0.1% Tween-20
Heated to 95°C for 5 min then cooled to 0°C for 10 min
Specifically binds to tumor markers in lung cancer serum
Apt-43 had the highest Kd among selected aptamers but was chosen by the authors as the best aptamer candidate in this study because it had the highest specificity to tumor markers in lung cancer serum.
5'-dCpdTpdApdTpdApdGpdCpdApdApdTpdGpdGpdTpdApdCpdGpdGpdTpdApdCpdTpdTpdCpdCpdTpdCpdTpdCpdApdGpdGpdTpdGpdGpdGpdTpdGpdTpdApdTpdGpdTpdGpdGpdGpdCpdTpdCpdCpdCpdTpdTpdTpdApdCpdTpdGpdApdTpdTpdGpdGpdGpdTpdCpdApdApdApdApdGpdTpdGpdCpdApdCpdGpdCpdTpdApdCpdTpdTpdTpdGpdCpdTpdApdAp-3'
88
27159.6 g/mole
830300 L/(mole·cm)
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Li K, Xiu C-L, Gao L-M, et al. Screening of specific nucleic acid aptamers binding tumor markers in the serum of the lung cancer patients and identification of their activities. Tumor Biology. 2017;39(7). doi:10.1177/1010428317717123
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