Aptagen, LLC
ASO15nt(APP) (ID# 9745)
DNA
Flanking sequence of APP 3′-UTR D-rG4
Other
0.4 ± 0.1 nM (reported value)
25 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 150 mM KCl
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
This is not technically an aptamer; it is an antisense oligonucleotide for a sequence adjacent to the target G-quadruplex. Forms an L-aptamer-ASO conjugate with L-Apt.4-1c. The 3' end has an azide modification. Molecular weight and extinction coefficients do not include the azide modification.
5'-dApdApdGpdApdCpdCpdApdGpdCpdApdGpdApdGpdCpdAp-3'
15
4604.1 g/mole
159800 L/(mole·cm)
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Zhao, H., Lau, H. L., Zhang, K., & Kwok, C. K. (2024). Selective recognition of RNA G-quadruplex in vitro and in cells by L-aptamer-D-oligonucleotide conjugate. Nucleic acids research, 52(22), 13544–13560. https://doi.org/10.1093/nar/gkae1034 L-RNA Aptamer-Based Tools for G-Quadruplex Structure: Identification, Characterization, and Application Danyang Ji, Kun Zhang, Maryana Yarshova, and Chun Kit Kwok Accounts of Chemical Research 2025 58 (21), 3247-3258 DOI: 10.1021/acs.accounts.5c00468
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