Aptamer Details

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a-Synuclein Oligomers (T-SO508) (ID# 7728)

a-synuclein oligomers
68 nM (reported value)
TBS-T buffer for ELONA assay: 10 mM Tris-HCl, 150 mM NaCl, 5 mM KCl, pH 7.4 with 0.05% Tween 20.
Heated to 95°C for 10 min, then cooled at a rate of 2°C/min to a final temperature of 25°C.
Cross-reactivity with AD-specific amyloid ? oligomers (Kd=25 nM).

Does not bind to a-synuclein monomers or fibrils or PQQGDH, C-reactive protein, or luciferase. Weakly binds to IgG.
CD spectrum suggests that this aptamer forms a G-quadruplex.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

K Tsukakoshi. Selection of DNA aptamers that recognize a-synuclein oligomers using a competitive screening method. Anal Chem. 84(2012): 5542-5547

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