Aptamer Details

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Short Mitomer2 against Mitochondria (ID# 7930)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: 2'-F-RNA

Target: Mitochondria

Antigen/Target Category: Other

Affinity (Kd): . nM (reported value)

Binding Conditions/Buffer: 20mM Tris-HCl, 2mM KCl, 40mM NaCl, 1mM MgCl2, 250mM Sucrose, pH=7.5

Binding Temp: 4°C

Refolding Protocol: 80C for 10 min, and cooled down slowly to 4C

Comments: Binding activity measured by fluorescence intensity within referenced paper. Due to presence of 2'F-CTP and 2'F-UTP, secondary structure may be inaccurate.

Sequence ():

Length: 20

Molecular Weight: 6342.71

Extinction Coefficient: 320500

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Yuri Tawaraya, Mamoru Hyodo, Mst Naznin Ara, Yuma Yamada, and Hideyoshi Harashima, RNA Aptamers for Targeting Mitochondria Using a Mitochondria-Based SELEX Method. Biol. Pharm. Bull. 37(8) 1411-1415 (2014). doi: 10.1248/bpb.b14-00112

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