Aptamer Details

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p-Nosyl Protected Alkyl Amino Group (M6b-M14) (ID# 7824)

p-nosyl protected alkyl amino groups
Small Organic
2.27 nM (reported value)
Optimized Buffer: 10 mM Na2HPO4, 2 mM KH2, 500 mM NaCl, pH 7.4.
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Competition binding assay performed by Mei et al. showed that the aptamer requires the entire p-nosyl-amide moiety.
Forms an anti-parallel G-quadruplex.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Mei H et al. (2012) Functional-group specific aptamers indirectly recognizing compounds with alkyl amino group. Anal. Chem. 84: 7323 - 7329

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