Aptamer Details

IR-A48 (ID# 605)

Aptamer Chemistry: DNA Target: Insulin Receptor Antigen/Target Category: Protein Affinity (Kd): 3.5 nM (reported value) Binding Conditions/Buffer: Krebs-Ringer HEPES Buffer. Tested in vivo. Binding Temp: 37°C Refolding Protocol: 95 C for 5 minutes, allowed to cool to room temperature. Comments: The 'N's in the structure indicate 5-[N-(1-naphthylmethyl)carboxamide]-2-deoxyuridine (Nap-dU) used in place of Thymine to improve binding efficiency.

Sequence (): 5'dCpdGpdCpdCpdTpdGpdGpdNpdGpdNpdNpdApdApdGpdApdCpdApdApdCpdCpdNpdCpdNpdApdGpdGpdNpdCpdApdGpdGpdCpdGp3' Length: 33 Molecular Weight: 10129.43 g/mole Extinction Coefficient: 313200 L/(mole·cm) GC Content: 70.37% nmoles/OD₂₆₀: 3.19 μg/OD₂₆₀: 32.34

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Yunn N, Koh A, Han S, Lim JH, Park S, et al. (2015) Agonistic Aptamer to the Insulin Receptor Leads to Biased Signaling and Functional Selectivity Through Allosteric Modulation. Nucleic Acids Research 1. doi:10.1093/narlgkv767

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Aptamer Details

IR-A48 (ID# 605)

Yunn N, Koh A, Han S, Lim JH, Park S, et al. (2015) Agonistic Aptamer to the Insulin Receptor Leads to Biased Signaling and Functional Selectivity Through Allosteric Modulation. Nucleic Acids Research 1. doi:10.1093/narlgkv767

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