Aptamer Details

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Parathyroid Hormone (PTH) (53–84) aptamer (ID# 9223)

Aptamer Chemistry: DNA

Target: Parathyroid Hormone (PTH) (53–84) (C-terminal fragment of Parathyroid Hormone)

Antigen/Target Category: Peptide

Affinity (Kd): 220.5 ± 57.5 nM (reported value)

Binding Conditions/Buffer: Phosphate-buffered saline (PBS)

Binding Temp: 25°C

Refolding Protocol: Not specified for heat refolding in the document

Specificity: Strong binding affinity to the C-terminal region of PTH. No significant cross-reactivity with other PTH fragments (PTH 1–34 or PTH 1–84)

Comments: Selected through SELEX as the most effective aptamer for PTH detection Incorporated into an electrochemical biosensor for sensitive and specific detection of PTH levels in clinical diagnostics.

Sequence ():

Length: 40

Molecular Weight: 13.2 kDa.

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Didarian, R., Bargh, S., Gülerman, A., Özalp, V.C., Erel, Ö. and Yildirim-Tirgil, N. (2025), Selection of DNA Aptamers Against Parathyroid Hormone for Electrochemical Impedimetric Biosensor System Development. Biotechnol Appl Biochem. e2745. https://doi.org/10.1002/bab.2745

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