Aptamer Details

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HM20 against Morphine-Like Opioids (ID# 9301)

Aptamer Chemistry: DNA

Target: Morphine-Like Opioids

Antigen/Target Category: Small Organic

Affinity (Kd): 1.11 ± 0.06 µM (reported value)

Binding Conditions/Buffer: 10 mM Tris−HCl (pH 7.4), 20 mM NaCl, and 0.5 mM MgCl2

Binding Temp: 25 °C °C

Refolding Protocol: The aptamer (final concentration: 0.5 μM) was first diluted in Tris buffer (final concentration: 10 mM, pH 7.4), heated to 95 °C for 10 min, and immediately cooled on ice for 1 min

Specificity: small-molecule opioids. Morphine-class opioids. Oxycodone-class opioids

Sequence ():

Length: 46

Molecular Weight: 14211.2 g/mole

Extinction Coefficient: 438900 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Canoura, J., Alkhamis, O., Venzke, M., Ly, P. T., & Xiao, Y. (2024). Developing Aptamer-Based Colorimetric Opioid Tests. JACS Au, 4(3), 1059–1072. https://doi.org/10.1021/jacsau.3c00801

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