Aptamer Details

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E22P-AbD43 (ID# 9547)

Aptamer Chemistry: RNA

Target: E22P–Ab42

Antigen/Target Category: Peptide

Affinity (Kd): 50 ± 5 nM (reported value)

Binding Temp: 37°C

Refolding Protocol: The RNA pool or the aptamer was denatured at 90 °C for 10 min and renatured rapidly on ice for 10 min for refolding before use in the following studies.

Sequence ():

Length: 77

Molecular Weight: 23318.6 g/mole

Extinction Coefficient: 667500 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Murakami K, Obata Y, Sekikawa A, Ueda H, Izuo N, Awano T, Takabe K, Shimizu T, Irie K. An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease. J Biol Chem. 2020 Apr 10;295(15):4870-4880. doi: 10.1074/jbc.RA119.010955.

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