Aptamer Details

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E22P-AbD43 (ID# 9547)

Aptamer Chemistry: RNA

Target: E22P–Ab42

Antigen/Target Category: Small Organic

Affinity (Kd): 50 ± 5 nM (reported value)

Binding Temp: 77.8°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 77

Molecular Weight: 23318.6 g/mole

Extinction Coefficient: 667500 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Murakami K, Obata Y, Sekikawa A, Ueda H, Izuo N, Awano T, Takabe K, Shimizu T, Irie K. An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease. J Biol Chem. 2020 Apr 10;295(15):4870-4880. doi: 10.1074/jbc.RA119.010955.

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